I really like the convenience of the flavored charcoal. I find that it maintains temperature more evenly than chips. I don’t have experience with mesquite but with other varieties, the flavor is super subtle at high temp direct burns. Indirect, low and slow, it can become overpowering. For low and slow I mix 5 or 6 to one flavored charcoal and that is the right balance for me.
Long way of saying, play around with it!